与HPV相关的多种类型鼻癌的临床病理学概况:系统性审查
João Paulo Gonçalves de Paiva1, Daniela Giraldo Roldán1, Ricardo Anderson de Oliveira Vasconcelos1
1Oral Diagnosis Department, Piracicaba Dental School, University of Campinas (UNICAMP), Av. Limeira, 901, Piracicaba, São Paulo, 13414-903, Brazil.
Head and neck pathology
|July 29, 2025
概括
这次对与HPV相关的多种类型鼻癌 (HMSC) 的系统审查发现,它是一种异质的恶性瘤,预后良好. 确定的诊断需要检测转录活跃的人类乳头瘤病毒 (HPV).
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 病毒学 病毒学
背景情况:
- 人类乳头瘤病毒 (HPV) 相关的多表型鼻癌 (HMSC) 是一种罕见的恶性瘤.
- 了解其临床病理和预后特征对于患者管理至关重要.
研究的目的:
- 系统地审查HMSC的临床病理学,预后特征和HPV基因造型模式.
- 巩固当前关于这种罕见的鼻恶性瘤的知识.
主要方法:
- 在PROSPERO.中注册的PRISMA 2020指南的系统审查.
- 包括来自主要数据库的案例报告,案例系列和队列研究 (2017-2025年).
- 描述性和关联分析,包括使用Joanna Briggs Institute工具进行Kaplan-Meier生存估计和质量评估.
主要成果:
- 分析了32项研究中的101例HMSC病例,主要是在60多岁的患者的鼻腔中.
- 微观发现包括基体形态,固体/形模式,高线粒活动,多形态和.
- 观察到强烈的p16表达,高的Ki67指数,以及HPV 33作为最常见的类型;大多数患者在手术后有良好的结果.
结论:
- HMSC是一种异质恶性病变,总体预后优异.
- 准确的诊断取决于通过in situ杂交或RT-PCR检测转录活性HPV.
- 虽然预后通常有利,但治疗,复发和转移会影响存活率.
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