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和多基基物质 (PFAS) 增强胆固醇积累,并调节巨细胞中的炎症反应

Jack C Connolly¹, Yasuhiro Ishihara², Emma Sawaya¹

¹Center for Health and the Environment, University of California, Davis, CA, 95616, USA.

Cardiovascular toxicology

|July 29, 2025

概括

暴露于和多醇基物质 (PFAS),特别是PFOA和PFOS,促进了巨细胞中的脂质积累,有助于泡细胞的形成和动脉样硬化. 这项研究突出了PFAS的重点.

科学领域:

环境健康环境健康
心血管生物学心血管生物学
毒理学毒理学毒理学

背景情况:

流行病学和动物研究将和多醇基物质 (PFAS) 暴露与心血管毒性和动脉样硬化联系起来.
泡细胞形成是早期动脉样硬化病变的一个关键事件,涉及巨细胞中的脂质积累.

研究的目的:

研究 perfluorooctanoic acid (PFOA) 和 perfluorooctane sulfonic acid (PFOS) 对巨细胞中的脂质积累的影响.
分析泡细胞形成和相关细胞通路的关键标志物.

主要方法:

人类U937衍生的巨细胞暴露于PFOA和PFOS.
对脂质和胆固醇积累,PPARγ活性,Nrf2激活,氧化应激标志物和基因表达 (IL-1β,PAI-2,CYP8B1,LSS,COX-2,AKR1C3,MMP-1,MMP-12,IL-6) 的分析.
评估细胞迁移和对激活的巨细胞的影响.

主要成果:

PFOA和PFOS显著增强了巨细胞中脂质和胆固醇的积累,这是泡细胞的特征.
暴露于PFAS诱导了过酶增殖器激活受体玛 (PPARγ) 活性和激活的 (NF) - 红色素衍生的2 (E2) 相关因子2 (Nrf2),诱导氧化应激.
提高IL-1β,PAI-2,COX-2,AKR1C3,MMP-1和MMP-12的调节,降低CYP8B1和LSS的调节. 此外,PFAS还调节了激活的巨细胞中的免疫反应.

结论:

暴露于PFAS促进了巨细胞中的脂质积累和泡细胞的形成.
暴露于PFAS会影响动脉样硬化的关键途径,包括脂质代谢,氧化应激和炎症.
研究结果表明,PFAS通过改变巨细胞功能和免疫反应,有助于动脉样硬化.

关键词:

心血管疾病是什么心血管疾病细胞因子 (cytokines) 是一种细胞因子.泡细胞是一种泡细胞.脂质脂质脂质是一种巨细胞是一个巨细胞.在PFAS中,有很多方法.这是一个PPAR.这就是SARS-CoV-2病毒.

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