通过96周的随机试验,高血压和血压变化与多卢特格拉维尔或比较抗逆转录病毒疗法在随机试验
Parul Patel1, Ana Milinkovic2, Richard Grove3
1ViiV Healthcare, Durham, NC, USA.
The Journal of antimicrobial chemotherapy
|July 29, 2025
概括
基于多卢特格拉维尔的抗逆转录病毒疗法 (ART) 在HIV-1患者中没有增加血压 (BP) 或发生高血压. 这一发现是基于随机试验评估ART治疗方案在未经治疗的个人.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 有限的数据存在于基于整合酶链转移抑制剂的疗法对血压 (BP) 的影响,包括基于dolutegravir的抗逆转录病毒疗法 (ART),在HIV-1 (PWH) 患者中.
- 评估血压变化和高血压发病率对于长期的艾滋病毒管理至关重要.
研究的目的:
- 为了评估ART原始的PWH随机分配到基于杜洛特格拉维尔的ART与替代比较ART (cART) 的血压变化和发生的高血压.
- 分析来自2/3期临床试验 (SPRING-1,SPRING-2,SINGLE,FLAMINGO) 的数据.
主要方法:
- 聚合的2/3期试验的后期分析.
- 在基线,第48周和第96周评估血压.
- 在没有基线高血压的参与者中,按血压值,不良事件或抗高血压药物的使用定义的事件高血压.
主要成果:
- 在没有基线高血压的1815名参与者中,在基于多卢特格拉维尔的ART (23%) 和cART (21%) 组之间,发生高血压的发生率在96周内是相似的.
- 在96周,两组之间没有观察到与基线相比血压变化的显著差异.
- 在这两组中,大约1%的参与者开始服用抗高血压药物.
结论:
- 含有多卢特格拉维尔的三种药物ART在没有初始高血压的ART-naivePWH中没有影响发生的高血压,直到96周.
- 这些发现表明,与其他cART疗法相比,基于多洛特格拉维尔的ART与高血压风险的增加无关.
相关概念视频
Hypertension IV: Drug Therapy and Lifestyle Modifications
37
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
37
Alterations in Blood Pressure
1.5K
Alterations in blood pressure, such as hypertension (high blood pressure) and hypotension (low blood pressure), significantly affect human health. Understanding these conditions' classifications, causes, and symptoms is essential for effective management and treatment.
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
Hypertension (High blood pressure)
Hypertension occurs when blood pressure readings consistently exceed the normal range. It is diagnosed when systolic blood pressure (the top number, indicating pressure while the heart...
1.5K
Hypertension III: Clinical Manifestations and Diagnostic Studies
48
Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
48
Hypertension and Regulation of Blood Pressure
3.1K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.1K
Antihypertensive Drugs: Angiotensin II Receptor Blockers
910
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
910
Antihypertensive Drugs: Direct Renin Inhibitors
817
The renin-angiotensin-aldosterone system (RAAS) is an intricate physiological pathway involving numerous enzymes and hormones, including renin, angiotensin-converting enzyme (ACE), angiotensin I and II, and aldosterone. Imbalances within this system increase the production of angiotensin II and aldosterone. Increased angiotensin II levels promote vasoconstriction and blood pressure elevation. Concurrently, higher aldosterone levels stimulate sodium and water reabsorption in the kidneys,...
817


