基于基因表达的简单血液生物标志物描述了与心血管健康相关的生物年龄
Natalia Hernández-Bellido1,2, Adrián Hernández-Vicente3,4, Laura García-Mendívil5,6
1Biomedical Signal Interpretation and Computational Simulation (BSICoS) Group, Instituto de Investigación en Ingeniería de Aragón (I3A), Universidad de Zaragoza, Zaragoza, Spain. nhbellido@unizar.es.
GeroScience
|July 29, 2025
概括
一种新的基因表达生物标志物GamC估计了生物年龄 (BA) 和心血管健康. 这种简单的工具跟踪了年龄超出时间表的衰老,并对运动做出了反应,帮助健康的衰老策略.
科学领域:
- 老年学和分子生物学
- 生物标志物发现发现
- 心血管健康研究 心血管健康研究
背景情况:
- 年代年龄 (CA) 不足以评估疾病风险;生物年龄 (BA) 估计对于个性化健康监测至关重要.
- 目前的BA工具往往接近CA或是复杂的,限制了临床翻译和实时健康状况评估.
- 需要简单,生物相关的生物标志物来监测衰老和心血管健康.
研究的目的:
- 介绍和描述基于基因表达的年龄监测钟 (GamC) 作为一种新的衰老生物标志物 (BOA).
- 通过将其与心血管 (CV) 健康指标和身体活动相关联来评估GamC的生物相关性.
- 评估GamC监测BA变化的能力,以应对干预措施.
主要方法:
- GamC是使用三个与衰老相关的基因的血液基因表达水平开发的:ABLIM1,CCR7和LEF1.
- GamC与CA的关联在三个独立的队列中使用全转录组数据进行了验证.
- 通过将GamC与身体活动,自主神经系统功能和对百岁老人运动干预的反应相关联来评估功能相关性.
主要成果:
- 在独立的队列中,GamC显示了与CA的中度,可靠的关联.
- GamC 具体反映了当前的身体活动水平,但与自主神经系统功能有很弱的相关性.
- 在百岁以上的人群中,GamC对运动干预的反应适度,这表明BA的监测潜力.
结论:
- GamC是一种简单,经济实惠的候选BOA,用于评估当前与心血管健康相关的生物年龄.
- GamC能够反映身体活动并响应干预措施的能力支持其用于促进健康衰老.
- 这种生物标志物为心血管健康监测和与年龄有关的疾病预防提供了广泛的临床转化.
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