唾液生物标志物作为焦虑,抑郁和压力的预测因素
Dana Gabriela Budala1, Ionut Luchian2, Dragos Ioan Virvescu3
1Department of Dentures, Faculty of Dental Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Current issues in molecular biology
|July 29, 2025
概括
唾液生物标志物如皮质醇和α-氨基酶可以表明急性压力,而其他生物标志物则在焦虑和抑郁症中显示慢性炎症. 这些非侵入性标志物显示出早期发现和个性化治疗精神健康障碍的前途.
科学领域:
- 神经内分泌学神经内分泌学
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 焦虑和抑郁与神经内分泌和免疫系统失调有关,特别是HPA轴和SAM系统.
- 唾液生物标志物提供了一种非侵入性方法来评估心理痛苦.
研究的目的:
- 审查目前关于焦虑,抑郁和压力的唾液生物标志物的证据.
- 为了综合对皮质醇,sAA,sIgA,CgA,IL-6,TNF-α,CRP,BDNF和miRNAs的发现.
主要方法:
- 从2010-2025年对文学进行叙事审查.
- 使用相关的MeSH术语对多个数据库进行全面搜索.
主要成果:
- 在唾液分析和与压力有关的疾病之间发现了一致的关联.
- 皮质醇和sAA反映了急性压力;细胞因子 (IL-6,TNF-α) 和CRP表明慢性炎症.
- BDNF和miRNA提供了对神经可塑性和基因调节的见解.
结论:
- 唾液生物标志物显示出早期检测,监测和个性化治疗情绪和焦虑障碍的潜力.
- 皮质醇和sAA是急性压力的关键,而细胞因子和CRP突出显示慢性炎症.
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