基于生物信息学和Omics的乳腺癌视角:促进针对性基因鉴定,用于开发抗癌剂
Irmasari Irmasari1,2, Alim Khodimul Rahmat3, I Made Bayu Kresna Yoga1,2
1Master's Student in Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara II, 55281 Yogyakarta, Indonesia.
Asian Pacific journal of cancer prevention : APJCP
|July 29, 2025
概括
生物信息学和奥米克学方法加速了从天然化合物和传统中医药 (TCM) 中发现乳腺癌药物. 这些方法提高了传统药物的疗效,支持临床应用的临床前验证.
科学领域:
- 在瘤学瘤学.
- 生物信息学是一种生物信息学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 乳腺癌是全球女性死亡的主要原因之一.
- 确定新的治疗点对于有效治疗至关重要.
- 生物信息学和奥米克斯方法为药物发现提供了创新的策略.
研究的目的:
- 通过使用生物信息学和奥米克学,审查从自然化合物和传统中医药 (TCM) 加速药物发现的情况.
- 探索这些天然产品与传统药物结合的潜力.
- 突出生物信息学工具和omics数据库在这个过程中的作用.
主要方法:
- 对过去五年研究的系统文献综述.
- 在PubMed,ScienceDirect和Scopus数据库中进行的搜索.
- 瑞安平台用于研究选择,将3800项研究缩小到70篇相关文章.
主要成果:
- 关键生物信息学方法的概述:数据挖掘,基因本体学 (GO) 丰富,基因和基因组的京都百科全书 (KEGG) 途径分析.
- 蛋白与蛋白相互作用 (PPI) 网络建设和枢纽基因选择确定了潜在的目标.
- 这些工具的应用加速了天然化合物和TCM的发现,提高了组合治疗的疗效.
结论:
- 了解omics数据库,网络服务器和软件有助于药物发现,并增强传统的乳腺癌治疗.
- 这种综合方法支持临床前验证 (体外和体内) 临床相关性.
更多相关视频
09:08Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
Published on: January 12, 2020
6.8K
07:47Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
Published on: September 15, 2023
1.7K
相关概念视频
02:57Targeted Cancer Therapies
7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.8K
02:50Combination Therapies and Personalized Medicine
5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K