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Updated: Sep 13, 2025

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异常的溶酶体动力学通过mTORC1信号扰乱了X链接的肌管神经病变中的神经生成

Kengo Kora1, Takeshi Yoshida1, Atsushi Yokoyama1

  • 1Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto 606-8507, Japan.

Brain : a journal of neurology
|July 29, 2025
PubMed
概括

链接到X的肌管肌病 (XLMTM) 是一种严重的先天性肌肉疾病. 这项研究揭示了肌管素缺乏会损害 lysosomal 动力学,导致 mTORC1 信号失调,这对肌肉发育至关重要,并建议将 mTORC1 作为治疗向.

关键词:
在MTM1中,MTM1是MTM1.链接到X的肌管神经病变是X链接的肌管神经病变诱导的多能干细胞干细胞.lysosomal 的动力学是什么?mTORC1的信号传输系统.肌源性差异化的分化

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