没有费用的治疗? 基于互联网的抑郁症干预的效果和副作用:随机对照试验
Anna Baumeister1, Lea Schuurmans1, Alina Bruhns1
1Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Martinistr. 52, Hamburg, 20246, Germany, +49 40 741053417.
JMIR mental health
|July 29, 2025
概括
基于互联网的抑郁症干预措施有效地减少了症状. 虽然一些用户报告了负面影响,但这些并没有影响整体结果,这表明在线心理健康支持的好处可能超过缺点.
科学领域:
- 数字心理健康数字心理健康
- 临床心理学 临床心理学
- 心理治疗的研究研究.
背景情况:
- 基于互联网的干预越来越多地用于抑郁症治疗,这是由于可访问性和成本效益.
- 然而,这些数字心理健康工具的潜在负面影响在很大程度上被忽视了.
- 本研究通过检查正面和负面结果来解决这一差距.
研究的目的:
- 评估未经指导的基于互联网的抑郁症干预措施的积极和消极影响.
- 将干预组与接受通常护理的等候名单对照组进行比较.
- 探索可能影响治疗结果的因素.
主要方法:
- 303名参与者使用重复测量混合模型进行了分析.
- 主要结局:贝克抑郁症库存-II (BDI-II) 在12周的变化.
- 二次结局包括PHQ-9,自尊,生活质量和通过PANEPS-I评估的负面影响.
主要成果:
- 与对照组相比,干预组显示抑郁症状 (BDI-II,PHQ-9) 的显著减少 (g=0.30-0.42).
- 在补充剂中观察到自尊和生活质量的改善,但在治疗意图分析中没有.
- 22-68%的参与者报告了负面影响,主要是与计划相关的问题,但没有影响整体治疗结果.
结论:
- 无指导的基于互联网的干预有效地减少了抑郁症状.
- 尽管存在负面影响,但它们并没有阻碍治疗的成功,这表明用户可能获得净益.
- 进一步的研究可以探索减轻数字心理健康干预负面影响的策略.
更多相关视频
08:20MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
Published on: August 11, 2015
14.1K
08:15Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
Published on: June 6, 2025
180
相关概念视频
01:54The Placebo Effect
6.3K
The placebo effect occurs when people's expectations or beliefs influence or determine their experience in a given situation. In other words, simply expecting something to happen can actually make it happen.
6.3K
01:18Depression: Overview
343
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
343
01:30Electroconvulsive Therapy
190
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
190
01:23Antidepressant Drugs: MAOIs and Other Agents
358
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
358
01:27Depressive Disorders: MDD and Dysthymia
217
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
217
01:03Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K