相关实验视频
Updated: Sep 13, 2025

06:16
The Miniature Pig: A Large Animal Model for Cochlear Implant Research
Published on: July 28, 2022
3.0K
迷你猪中的耳新鲜基底膜的机械特性
Songbo Xue1, Yang Zhao2, Xu Tian2
1Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China; Chinese Academy of Medical Sciences & Peking Union Medical College Hospital, Beijing 100730, China.
Journal of biomechanics
|July 29, 2025
概括
微型猪基底膜 (BM) 生物力学揭示了脆弱性的显著区域差异. 电极设计必须尽量减少对脆弱的远部BM区域的插入力,以提高耳植入物安全性和保护听力.
科学领域:
- 生物力学 生物力学
- 耳植入器技术 耳植入器技术
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 耳植入是严重听力损失的重要治疗方法.
- 优化电极设计和手术技术对于安全性和有效性至关重要.
- 了解基底膜 (BM) 的机械特性是最大限度地减少插入创伤的关键.
研究的目的:
- 为了研究小型猪基底膜 (BM) 的生物力学特性.
- 为优化耳植入物电极设计和外科安全提供数据.
- 为了确定BM最容易受到插入创伤的区域.
主要方法:
- 在16个小型猪尾上进行了纳米痕和破裂测试.
- 使用90微米的探头测量力位移曲线和破裂力.
- 扬模量在四个不同的耳角 (90°,180°,270°,360°) 测量.
主要成果:
- 断裂力和扬模量在BM的不同区域有显著的差异.
- 脊髓的远端区域表现出更高的脆弱性和减少的度.
- 中位破裂力在20mN至56mN之间,Young的模量中位数在1.30MPa至1.65MPa之间.
结论:
- 基底膜 (BM) 向远端变得越来越灵活和脆弱.
- 耳植入物电极设计应优化,以减少脆弱的远部区域的插入力.
- 这些生物机械数据作为改善外科手术方案和开发更安全的电极插入系统的基准.
相关概念视频
The Cochlea
46.0K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
46.0K
Hair Cells
41.4K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
41.4K
Anatomy of the Ear
8.9K
Auditory sensation, commonly called hearing, involves the transformation of sonic waves into neural impulses facilitated by the structures of the auditory organ. The prominent, flesh-like structure on the side of the head, called the auricle, directs sound waves towards the auditory canal. The auricle is often mislabeled as the pinna, a term more aligned with mobile structures like a feline's external ear. The auditory canal penetrates the cranium via the external auditory meatus of the...
8.9K

