细胞内膜网膜应激在BPS诱导的子宫内膜断层破坏中的作用
Shaoyuan Xu1, Zhaoping Tan2, Ruiqing Zhang2
1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China; Reproductive Medicine Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei 442000, China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei 430071, China; Hubei Clinical Research Center for Reproductive Medicine, Shiyan, Hubei 442000, China.
双S (BPS) 暴露可能通过通过内质网膜 (ER) 应激扰乱子宫内膜分泌,从而阻碍生育,影响辅助生殖技术 (ART) 中的植入率.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 毒理学 毒理学 毒理学
背景情况:
- 双A (BPA) 的替代品,如双S (BPS) 已经普遍存在,人们越来越担心它们对健康的影响.
- 以前的研究将BPA与生殖损害联系起来; BPS的影响仍然不太清楚.
- 子宫内膜分泌对于成功怀孕和植入至关重要.
研究的目的:
- 研究双S (BPS) 对人类子宫内膜层细胞 (HESCs) 的影响.
- 探索潜在的机制,特别是内质网膜 (ER) 压力.
- 在接受辅助生殖技术 (ART) 的患者中,评估BPS水平与植入/复发植入失败 (RIF) 之间的关联.
主要方法:
- 在接受ART的不孕症患者中分析血清和尿液BPS度.
- 在决定化过程中,HESCs在体外暴露于不同度的BPS.
- 评估HESC的扩散,决定化标志物 (PRL,IGFBP1) 和ER压力标志物 (XBP1-s,ATF4,IRE1α).
- 评估ER压力抑制剂对BPS诱导变化的影响.
主要成果:
- 在血清BPS水平高的患者中观察到更低的植入率.
- 在患有复发性植入失败 (RIF) 的患者中尿液BPS水平升高.
- 在实验室中,BPS抑制了HESC的扩散和决定化标志物.
- 在HESC中,BPS暴露诱导了ER压力,由分子标记物和超结构变化证实.
- ER压力抑制剂逆转了BPS诱导的决定化的抑制.
结论:
- 双S (BPS) 污染可能会通过ER应激激活损害子宫内膜分泌.
- BPS暴露与植入率降低和复发植入失败 (RIF) 有关.
- 这些发现突出了BPS在生殖健康和ART结果中的潜在风险.
相关概念视频
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Smooth Endoplasmic Reticulum
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