与冠状动脉样硬化相关的不同血生物标志物模式在低风险与高风险个体之间 - 一项观察性横截面研究
Sofia Cederström1, Yunzhang Wang1, Pia Lundman1
1Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Atherosclerosis
|July 29, 2025
概括
冠状动脉疾病 (CAD) 的血生物标志物在低和高心血管疾病 (CVD) 风险组之间有所不同. 识别这些独特的模式,包括分支链氨基酸和高密度脂蛋白 (HDL) 代谢物,有助于了解用于初级预防的CAD风险因素.
科学领域:
- 生物化学 生物化学
- 心血管医学 心血管医学
- 生物标志物发现发现
背景情况:
- 冠状动脉疾病 (CAD) 和心血管疾病 (CVD) 事件与全身血液生物标志物有关.
- 有针对性的奥米克技术为识别这些生物标志物提供了潜力.
- 了解这些关联对于初级预防策略至关重要.
研究的目的:
- 调查血蛋白和代谢物生物标志物和亚临床CAD之间的关联.
- 为了比较低风险与高风险心血管疾病人群中的这些关联.
- 识别与亚临床动脉样硬化相关的不同生物标志物模式.
主要方法:
- 使用了瑞典心肺生物图像研究 (SCAPIS) 队列.
- 参与者分为低 (<5% SCORE2) 和高 (>7.5% SCORE2) 的心血管疾病风险组.
- 采用随机森林和顺序逻辑回归来分析409种蛋白质和代谢物与冠状动脉分数 (CACS) 和冠状动脉样硬化 (SIS) 的部分相比.
主要成果:
- 在低风险个体中,分支链氨基酸与CACS和SIS相关;高密度脂蛋白 (HDL) 代谢物 (不包括脂) 与较低的CACS和SIS有关.
- 在高风险人群中,炎症蛋白与冠状动脉样硬化有负面关联;高脂代谢物缺乏保护作用.
- 列宁和MMP12在两个风险组中都与亚临床CAD有关.
结论:
- 显著的血生物标志物模式与低风险和高风险人群中的亚临床CAD有关.
- 这些发现可以提高对CAD在初级预防中的保护性和风险因素的理解.
- 基于心血管风险分层,生物标志物概况有显著差异.
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