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通过角膜共聚焦显微镜评估的角膜神经和树突细胞参数是否是多发性硬化症的良好标志物? - 一个系统的审查和元分析

Prince K Akowuah¹, Esther Botchway², Ebenezer Owusu¹

¹College of Optometry, University of Houston, Houston, TX, USA.

Journal of neuroimmunology

|July 29, 2025

概括

与对照组相比,多发性硬化症 (MS) 患者的角膜神经密度降低,角膜树突细胞数量发生变化. 角膜共聚焦显微镜可以帮助监测多发性硬化症的进展.

科学领域:

眼科医生眼科眼科
神经学神经学
免疫学免疫学免疫学

背景情况:

多发性硬化症 (MS) 是一种影响中枢神经系统的脱髓化疾病.
角质神经和免疫细胞的改变可能成为神经疾病的潜在生物标志物.

研究的目的:

评估和比较多发性硬化症 (MS) 患者与健康对照者的角膜神经和树突细胞变化.
评估角膜成像在MS监测中的潜力.

主要方法:

一项对12项涉及485名多发性硬化患者和319名对照患者的横截面比较研究的系统审查和元分析.
数据来源于PubMed,Scopus和Web of Science,并遵循PRISMA指南.数据来源于PubMed,Scopus和Web of Science,并遵循PRISMA指南.数据来源于PubMed,Scopus和Web of Science,并遵循PRISMA指南.数据来源于PubMed,Scopus和Web of Science,并遵循PRISMA指南.数据来源于PubMed,Scopus和Web of Science.
结果分析使用 95% 置信区间的平均差异 (MD),并使用 GRADE 系统评估证据质量.

主要成果:

与健康对照人群相比,多发性硬化患者的角膜神经纤维密度,长度和分支密度明显较低.
没有观察到角膜树突细胞密度的总体显著差异,但患有疾病持续时间≤8年的多发性硬化患者的密度较高.
在角膜神经纤维密度和长度方面发现了显著的异质性.

结论:

角膜神经退化和变化的树突细胞群体在多发性硬化症中很明显.
角膜共聚焦显微镜为MS疾病监测提供了一个潜在的新兴工具.
需要进一步的纵向研究来验证这些发现及其与MS进展和严重程度的相关性.

关键词:

视角膜视角膜是一个树状细胞树状细胞多发性硬化症是多发性硬化症.神经纤维的神经纤维神经组织的神经组织.

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