在接受放射治疗的乳腺癌患者中,患者报告了症状毒性的结果
Nidhi Gupta1, Aanchal Arora2, Kislay Dimri1
1Department of Radiation Oncology, Government Medical College and Hospital, Chandigarh, India.
Current problems in cancer
|July 29, 2025
概括
在接受放射治疗的乳腺癌患者中,患者报告的结果 (PRO) 通常显示出比医生报告的结果 (PhyRO) 更高的症状毒性. 将PRO与PhyRO相结合,可以提高患者的护理和结果.
科学领域:
- 在瘤学瘤学.
- 辐射疗法 辐射疗法
- 患者报告的研究结果研究结果
背景情况:
- 患者报告的结果 (PRO) 经常显示出比医生报告的结果 (PhyRO) 更大的症状毒性.
- 这项研究调查了在辅助放射治疗期间乳腺癌患者的PRO症状毒性,并将其与PhyRO进行比较.
- 还分析了影响症状严重程度和与健康相关的生活质量 (QoL) 的因素.
研究的目的:
- 为了比较患者报告的结果 (PRO) 与医生报告的结果 (PhyRO) 在接受辅助放射治疗的乳腺癌患者的症状毒性.
- 为了确定与患者报告的症状严重程度相关的因素.
- 评估对与健康相关的生活质量 (QoL) 的影响.
主要方法:
- 67名接受辅助放射治疗的乳腺癌患者的潜在招募.
- 使用CTCAE v5.0进行PhyRO评估;使用PRO CTCAE v1.0.0进行PRO评估;使用PRO CTCAE v1.0.0进行PRO评估.
- 对于PRO-PhyRO协议的加权卡帕统计数据;对于QoL的EQ-5D-5L.
主要成果:
- 总的来说,PRO和PhyRO之间的一致性很差,对于恶心,疼痛和皮肤炎等特定症状的一致性相当或几乎完美.
- 与较低的PhyRO毒性相关的因素包括老年患者年龄,较高的识字率和特定的治疗方式.
- 根据报告的毒性严重程度,QoL实用值没有显著差异.
结论:
- 在日常临床护理中,PRO为PhyRO提供了有价值的补充信息.
- 整合PRO可以改善患者的护理,治疗遵从性和临床结果.
- 建议在乳腺癌放射治疗管理中常规使用PRO.
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