在中年和老年人中,动脉衰竭和认知功能变化的关联
Jeongran Ko1, Byeong-Hwan Jeon2, Junghoon Kim1
1Sports and Exercise Medicine Laboratory, National Korea Maritime & Ocean University, Busan, 49112, Republic of Korea.
Public health
|July 29, 2025
概括
低肌肉强度 (动力衰竭) 与老年人轻度认知障碍 (MCI) 的风险更高有关. 无论是新的还是正在进行的动脉动脉症,都会随着时间的推移增加患MCI的可能性.
科学领域:
- 老年学是一门学科.
- 神经学 神经学
- 运动学 运动学
背景情况:
- 与年龄相关的肌肉力量丧失,即动力衰竭,越来越多地被认为是老年人群的重大健康问题.
- 肌肉强度下降,特别是手握强度下降,与认知障碍有关,这表明通过神经肌肉系统衰退存在潜在联系.
- 然而,肌肉强度下降和认知功能变化之间的时间关系,包括新发轻度认知障碍 (MCI),需要进一步调查.
研究的目的:
- 研究重复测量肌肉强度与认知功能变化之间的纵向关系.
- 检查活力衰竭和中年和老年人新发轻度认知障碍 (MCI) 的风险之间的关联.
主要方法:
- 一项前性队列研究,利用韩国老化纵向研究 (2006-2020) 的数据.
- 包括10,516名45岁及以上的成年人.
- 肌肉强度通过手握强度评估,动力衰减定义为<28公斤 (男性) 或<18公斤 (女性). 根据韩国迷你精神状态考试得分定义的MCI <24.
主要成果:
- 重复测量分析表明,MCI与动脉动力症相关的几率明显更高 (OR 1.84),绝对握手强度最低 (OR 2.07) 和相对握手强度最低 (OR 2.17).
- 在长达14年的随访期间,新诊断的动脉缩症 (HR 1.29) 和持续的动脉缩症 (HR 1.29) 都与新发性MCI的风险增加有关.
- 这些发现强调了肌肉力量减少和认知能力下降之间的一致联系.
结论:
- 动力衰竭和整体肌肉力量低下是MCI随着时间的推移而发展的重要危险因素.
- 动脉的发病和持续都与中年和老年韩国成年人中新发病的MCI风险增加有关.
- 这些结果强调了肌肉力量维护对老年人群认知健康的重要性.
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