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Updated: Sep 13, 2025

Real-Time Monitoring of Aurora kinase A Activation using Conformational FRET Biosensors in Live Cells
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Published on: July 30, 2020

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发现了第一类的 Aurora B 激酶选择性降解剂

Xiaoping Hu1, Kevin Graciano2, Jianping Hu1

  • 1Mount Sinai Center for Therapeutics Discovery, Departments of Pharmacological Science, Oncological Science and Neuroscience, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, United States.

European journal of medicinal chemistry
|July 29, 2025
PubMed
概括

研究人员开发了MS44,这是AURKB的第一个选择性降解剂. 这种新型的蛋白质溶解向嵌合体 (PROTAC) 有效地降解了AURKB,抑制了癌细胞的增殖,并提供了潜在的新疗法策略.

关键词:
AZD115222 的使用情况.极光 B 极光 B 极光降解器降解器降解器基因酶激酶的使用方法这就是PROTAC.

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