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怀孕期糖尿病妊娠中实时连续葡萄糖监测:一个随机对照试验

Amy M Valent¹, Michaela Rickert¹, Christian Huerta Pagan¹

¹School of Medicine, Department of Obstetrics & Gynecology, Division Maternal-Fetal Medicine, Oregon Health & Science University, Portland, OR.

|July 29, 2025

概括

实时连续血糖监测 (CGM) 显著改善了妊娠糖尿病 (GDM) 的孕妇的血糖时间范围. 这种先进的监测方法比传统的毛细血管血糖检测提供了更好的血糖控制.

科学领域:

内分泌学在内分泌学.
孕产妇和胎儿医学孕产妇和胎儿医学
医疗技术医疗技术医学技术

背景情况:

孕期糖尿病 (GDM) 需要在怀孕期间仔细监测葡萄糖.
传统的毛细血管血糖 (CBG) 监测可能无法提供全面的血糖图像.
实时连续血糖监测 (CGM) 提供连续数据,以改善管理.

研究的目的:

为了比较实时CGM与CBG监测的有效性,以达到GDM孕妇的目标葡萄糖时间范围 (%TIR).
评估CGM对GDM怀孕中的血糖控制指标的影响.

主要方法:

进行了一项开放标签,单中心随机对照试验.
患有GDM的孕妇被随机分配 (2:1) 给实时CGM加CBG或单独CBG.
主要结局是从招生到分娩的%TIR (60-140 mg/dL).

主要成果:

与CBG组 (88% ± 14; P = 0.027) 相比,CGM组实现了明显更高的%TIR (93% ± 6).
干预组表现出较高的白天TIR和较低的平均24小时和白天葡萄糖水平.
在CGM组中,较少的参与者经历了超过140 mg/dL的时间.

结论:

与CBG监测相比,实时CGM显著增加了GDM怀孕个体的%TIR.
需要进行进一步的研究,以确定CGM衍生的改善的葡萄糖水平是否会影响围产和新生儿结局.

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