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Updated: Sep 13, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

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干扰素驱动的CAF重编程增加了结直肠癌中对新辅助放射治疗的免疫反应

Lili Huang1, Weiqing Lu1, Ruiyan Wu1

  • 1Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Clinical Research Center for Radiation Oncology, Shanghai 20032, China; Shanghai Key Laboratory of Radiation Oncology, Shanghai 20032, China.

Cell reports. Medicine
|July 29, 2025
PubMed
概括

经过干扰素许可的癌症相关纤维细胞 (CAFs) 通过招募免疫细胞来增强直肠癌放射治疗反应. 激活CAF中的STING信号增强了抗瘤免疫力,提高了放射治疗的疗效.

关键词:
这些CAF是CAF.通过IFN/STING通道.刺痛激动剂 刺痛激动剂 刺痛激动剂cDC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC1DC2DC1DC1DC2DC2DC2DC2DC2DC3DC4DC4DC4DC5辐射辐射辐射辐射的辐射

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