50岁及以上肺栓塞患者因特定原因死亡率的时间趋势
相关实验视频
Updated: Sep 13, 2025

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A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
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Katarina Glise Sandblad1,2, Kristina Svennerholm3,4, Jacob Philipson1,2
1Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Thrombosis and haemostasis
|July 29, 2025
概括
癌症仍然是老年肺栓塞 (PE) 患者的主要死亡原因,尽管致命的静脉血栓塞 (VTE) 和心血管死亡率有所下降,但总体病例率稳定. 在患有或没有已知的癌症的PE患者中,趋势不同.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 肺栓塞 (PE) 与高死亡率有关.
- 关于PE患者因特定原因死亡趋势的数据有限.
- 了解这些趋势对于改善患者治疗结果至关重要.
研究的目的:
- 调查50岁及以上PE患者因特定原因死亡的时间趋势.
- 分析三个不同时期 (2006-2011,2012-2017,2018-2023) 的死亡率趋势.
- 检查匹配对照和特定PE患者子组的死亡率趋势.
主要方法:
- 全国范围的瑞典注册研究首次PE患者和匹配的对照.
- 评估30天和31至365天因特定原因死亡率.
- 根据年龄和性别调整的波桑回归用于确定年度死亡率趋势的相对风险.
主要成果:
- 在PE患者中,癌症是30天死亡率 (稳定在4.7%) 和31至365天死亡率 (稳定在11.8%至11.4%) 的主要原因.
- 在研究期间,致命的静脉血栓栓塞 (VTE) 和心血管疾病的死亡率显著下降.
- 亚组分析显示,已知癌症的PE患者的癌症死亡率下降,但未知癌症患者的癌症死亡率增加.
结论:
- 癌症是年龄≥50岁的PE患者的主要死亡原因,其总体率稳定,这是由于已知癌症和没有癌症的患者的相反趋势所驱动的.
- 近年来,致命的VTE占总死亡率的比例很小.
- 这些发现突显了PE患者死亡率的不断变化以及癌症管理的关键作用.
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