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电流方向对1Hz运动皮层rTMS的影响

Carolina Kanig¹, Mirja Osnabruegge¹, Florian Schwitzgebel²

¹Department of Human Sciences, Institute of Psychology, University of the Bundeswehr Munich, Werner-Heisenberg-Weg 39, Neubiberg 85577, Germany; Department of Psychiatry and Psychotherapy, University of Regensburg, Universitätsstraße 31, Regensburg 93053, Germany.

Brain research bulletin

|July 29, 2025

概括

这项研究调查了重复性横磁刺激 (rTMS),发现后前前后 (PA-AP) 电流方向显著增强了运动皮质可塑性标志物. 这些发现强调了报告刺激参数对rTMS可靠性的重要性.

科学领域:

神经科学是一个神经科学.
神经调节是一种神经调节.
运动皮层可塑性运动皮层可塑性

背景情况:

重复性横磁性刺激 (rTMS) 的效果是高度可变的,缺乏可复制性.
电流的方向是影响rTMS后果的已知因素.
了解这些因素对于优化RTMS协议至关重要.

研究的目的:

为了研究电流方向对皮层和外围标志物的影响,由1HzrTMS诱导的运动皮层可塑性.
检查皮质和外围标记物之间的相关性.
确定影响RTMS结果的潜在混变量.

主要方法:

25名健康受试者在110%的静止运动值下接受了2000次1赫兹rTMS脉冲.
在前后向后前 (AP-PA) 和后后向前后 (PA-AP) 电流方向中,对左侧运动热点进行了刺激.
在使用单个脉冲的rTMS之前和之后,通过神经导航机器人辅助设置引导卷轴的放置,评估了运动唤起的潜力 (MEP) 和跨唤起的潜力 (TEP).

主要成果:

1 Hz的rTMS诱导了MEP和TEP组件 (N15,N45,P60) 的更高的振幅,并减少了N100的振幅.
与AP-PA相比,目前的PA-AP方向对欧洲议员和TEP产生了更强烈的影响.
延迟变化 (延长MEP和N15,缩短N100) 在PA-AP刺激时更加明显.

结论:

研究结果表明,1 Hz rTMS具有促进作用,与抑制性假设形成鲜明对比.
当前方向显著影响rTMS诱导的可塑性,支持不同神经元群体的激活.
精确报告和控制刺激参数,如电流方向,对于提高RTMS可靠性和可复制性至关重要.

关键词:

皮层刺激性皮层刺激性电流的方向电流的方向发动机唤起的潜力 (MEP)重复性横性磁性刺激 (rTMS) 是一种治疗方法.超唤起潜力 (TEP) 是一个潜在的潜力.

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