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心血管指数和氧化平衡在晚期心血管-脏-代谢综合征
Zhaoqi Yan1, Xiangyi Pu1, Xing Chang1
1Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Obesity (Silver Spring, Md.)
|July 29, 2025
概括
较高的氧化平衡得分 (OBS) 与心血管--代谢 (CKM) 综合征风险的降低有关. 像AIP和CMI这样的心血管指数可能会调解这种关联,建议新的风险降低策略.
科学领域:
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢健康 代谢健康
- 营养科学 营养科学
背景情况:
- 心血管--代谢 (CKM) 综合征对健康造成重大负担.
- 目前对CKM综合征的风险降低策略是不够的.
- 了解可修改的风险因素对于治疗CKM综合征至关重要.
研究的目的:
- 调查氧化平衡得分 (OBS) 与晚期CKM综合征的风险之间的关联.
- 探索心血管指数的调解作用,特别是血动脉质指数 (AIP) 和心脏代谢指数 (CMI).
- 确定影响CKM综合征风险的关键营养和生活方式因素.
主要方法:
- 对患有CKM综合征的成年人NHANES数据的分析,分为早期和高级阶段.
- 多变量后勤回归用于评估OBS (总体,饮食,生活方式) 和高级CKM之间的关系.
- 调解分析和夏普利添加式解释 (SHAP) 来评估指数的重要性和调解效应.
主要成果:
- 较高的OBS总值 (≥28) 与较低的分数 (≤16) 相比,与36%较低的晚期CKM综合征风险显著相关.
- 较高的AIP (>0.56) 和CMI (>0.57) 与较高的晚期CKM风险有关.
- 在OBS-CKM风险关联中,AIP和CMI可能分别占0.68%和4.08%的风险关联. 胡卜素和氨酸是主要的贡献者.
结论:
- 这项研究揭示了较高的OBS和高级CKM综合征风险之间的反向关联.
- 心血管指数 (AIP,CMI) 可能在OBS-CKM关系中起到调解作用.
- 这些发现为未来研究CKM综合征的因果途径和干预措施提供了基础.
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