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Updated: Sep 13, 2025

Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules
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Protein WISDOM: A Workbench for In silico De novo Design of BioMolecules

Published on: July 25, 2013

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基于安全模型的优化,平衡蛋白质序列设计的探索和可靠性

Shuuki Takizawa1, Keita Mori2, Naoto Tanishiki2

  • 1Research Division, Chugai Pharmaceutical Co., Ltd, Yokohama, Japan. takizawa.syuki85@chugai-pharm.co.jp.

Scientific reports
|July 29, 2025
PubMed
概括

蛋白质工程通过基于模型的优化 (MBO) 加速,但模型可能不可靠. 一种新的方法,即平均偏差树结构的帕森估计器 (MD-TPE),通过惩罚不可靠的预测来改善MBO,从而导致更好的蛋白质设计.

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