神经退行性疾病的鼻内输送途径:最近的见解和未来的方向
Jorge Correale1,2,3, Vanesa Mattera4, Juana Maria Pasquini4
1Departamento de Química Biológica e Instituto de Química y Fisicoquímica Biológicas (IQUIFIB), Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina. jcorreale@fleni.org.ar.
Drug delivery and translational research
|July 29, 2025
概括
内鼻分娩为绕过血脑屏障治疗神经退行性疾病提供了一条有希望的途径. 本综述探讨了用于中枢神经系统 (CNS) 疗法的鼻内 (IN) 施用方面的进展和挑战.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学 是一个学科.
- 药物运输 药物运输 药物运输
背景情况:
- 神经退行性疾病对全球健康构成越来越大的挑战,尤其是对老年人来说.
- 目前的治疗方法受到血脑屏障 (BBB) 的限制,阻碍了药物疗效.
- 有效的药物输送到中枢神经系统 (CNS) 对于治疗成功至关重要.
研究的目的:
- 审查最近在神经退行性疾病中向中枢神经系统输送治疗分子方面的进展.
- 探索使用鼻内 (IN) 途径克服BBB的策略.
- 评估从临床前模型到临床实践的IN交付的转化.
主要方法:
- 对中枢神经系统疾病的鼻内药物输送进行临床前研究的审查.
- 对最近的临床试验进行分析,评估用于神经退行性疾病的IN配方.
- 探索基于纳米粒子的新型IN传递系统.
主要成果:
- 在临床前的模型中,鼻内路线显示出向中枢神经系统输送各种药物 (蛋白质,miRNA,寡核酸) 的前景.
- 与免费药物相比,纳米颗粒配方可能会提高IN药物管理的疗效.
- 从动物模型转化到人类临床试验,将IN传递效率转化为人类临床试验仍然存在挑战.
结论:
- 鼻内注射是中枢神经系统药物输送的可行策略,比口服和静脉注射更有优势.
- 需要进一步的研究和精心设计的临床试验,以优化神经退行性疾病治疗的IN输送.
- 像纳米颗粒这样的新型配方有可能通过IN路线改善治疗结果.
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