母乳乳化剂的消费会改变后代早期的微生物群和杯状细胞功能,导致长期的疾病易感性
Clara Delaroque1,2, Héloïse Rytter1, Erica Bonazzi1,2
1Microbiome-Host Interactions, Institut Pasteur, Université Paris Cité, INSERM U1306, Paris, France.
Nature communications
|July 29, 2025
概括
母亲饮食乳化剂的摄入改变了后代的微生物群,增加了对结肠炎和代谢综合征的易感性. 这些变化与年轻小鼠的炎症和过早免疫发育有关.
科学领域:
- 微生物组研究的研究.
- 发育免疫学 发育免疫学
- 营养科学 营养科学
背景情况:
- 早期的微生物殖民和免疫系统的发展显著影响长期健康.
- 食成分,如乳化剂,可能会影响母体和后代的微生物群.
- 肠道微生物组的破坏与炎症和代谢疾病有关.
研究的目的:
- 研究母亲饮食乳化剂消费对后代微生物群和免疫发育的影响.
- 确定这些变化是否会增加对微生物群介导疾病 (如结肠炎和代谢综合征) 的易感性.
- 阐明这些跨代效应背后的机制.
主要方法:
- 在哺乳期,小鼠母被食含有碳氧甲基纤维素和聚酸盐-80的饮食.
- 对后代的微生物群进行了改变分析.
- 在年轻的成年后代中评估了对大肠炎和代谢综合征的敏感性.
- 检查了包括鞭毛素水平,细菌侵占和杯细胞相关抗原通道 (GAPs) 在内的机制.
主要成果:
- 母亲吸收乳化剂导致后代微生物群的短暂变化.
- 这些变化足以增加成人患大肠炎和代谢综合征的可能性.
- 后代表现出高水平的促炎性鞭毛素,细菌侵占,以及GAPs的过早关闭.
- 防止GAP关闭在药理上减轻了母乳乳化剂消费的有害影响.
结论:
- 食乳化剂可以诱导后代微生物组的跨代变化.
- 这些变化导致免疫发育加速,并增加对炎症性疾病的易感性.
- 针对特定的微生物与宿主相互作用,如GAPs,可能提供针对乳化剂诱导的健康风险的治疗策略.
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