相关实验视频

Updated: Apr 24, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
11:34

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

Published on: May 5, 2014

13.9K

模拟和积极学习可以有效地识别经过实验验证的广泛冠状病毒抑制剂

Katarina Elez1, Tim Hempel1,2,3, Jonathan H Shrimp4

  • 1Department of Mathematics and Computer Science, Freie Universität Berlin, Berlin, Germany.

Nature communications
|July 29, 2025
PubMed
概括

这项研究引入了一个新的药物查框架,结合了分子动力学模拟和积极学习. 该方法有效地识别了强大的抑制剂,如TMPRSS2的BMS-262084,降低了药物发现的成本和实验测试.

更多相关视频

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses12:23

In Vitro Selection of Aptamers to Differentiate Infectious from Non-Infectious Viruses

Published on: September 7, 2022

1.8K
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

1.5K

相关概念视频

Inhibitors of Viral Protein Synthesis01:30

Inhibitors of Viral Protein Synthesis

Protein synthesis is indispensable for viral replication, as viruses lack the cellular machinery required for this process and must hijack the host's translational apparatus. In response, host cells deploy a critical innate immune defense involving interferons, specialized cytokines that play a central role in inhibiting viral propagation.Upon viral detection, infected cells release interferons that bind to receptors on adjacent uninfected cells, activating the JAK-STAT signaling pathway and...
55