间歇性禁食和无糖饮食治疗长期COVID症状:一个随机交叉试验
Thomas Bunker1, Benjamin D Horne2,3, Mark D Baldwin4
1Independent Patient Researcher, Boulder, CO, USA. BunkColo@gmail.com.
Scientific reports
|July 29, 2025
概括
间歇性禁食,包括时间限制饮食 (TRE) 和更长的禁食期间,有效地减少了长期COVID症状. 更强烈的禁食方案在改善患者报告的结果和减少症状数量方面表现出卓越的有效性.
科学领域:
- 代谢健康 代谢健康
- 传染病研究 传染病研究
- 临床营养学 临床营养学
背景情况:
- 长期COVID (LC) 是一种普遍影响日常生活和社会互动的疾病.
- 目前对LC症状的治疗策略有限,需要新的干预措施.
- 间歇性禁食 (IF) 已成为炎症和代谢过程的潜在调节者.
研究的目的:
- 为了比较两个IF疗法的疗效和安全性,以缓解患者报告的长期COVID症状.
- 评估1-2天禁食对轻度时间限制饮食 (TRE) 对LC症状严重程度和数量的影响.
- 评估10周随机交叉试验中的症状变化,包括限制饮食.
主要方法:
- 一个为期10周的随机交叉试验,涉及2周的运行,随后是4周的TRE或4周的1-2天禁食,随后是交叉.
- 在整个干预期内,参与者遵循限制的无糖饮食.
- 每周在线调查评估了患者报告的LC症状严重程度 (LC-Scores) 和症状数量 (numLCsym).
主要成果:
- 禁食在降低LC症状严重程度方面明显优于单独TRE (p=0.008).
- 与TRE (-1.4) (p=0.002) 相比,LC症状的数量在禁食时 (-5.0) 减少得更为显著.
- 整体10周治疗方案显著降低了平均LC-score的51.8%和numLCsym的40.6%.
结论:
- 这两种间歇性禁食干预都在10周内显著减少了长期COVID症状.
- 与单独TRE相比,更强烈的禁食方案在减少LC症状严重程度和数量方面产生了明显更好的结果.
- 间歇性禁食,特别是更密集的禁食方案,为管理长期COVID症状提供了一种安全有效的治疗方法.
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