左桃体的改变调解了负面症状对精神分裂症社会功能障碍的影响
Jin Fang1, Yunshan Hu1, Yan Li1
1Department of Geriatric Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiangsu, 210029, China.
Schizophrenia (Heidelberg, Germany)
|July 29, 2025
概括
结构和功能性杏仁体 (AMYG) 变化,特别是在左侧的AMYG,与精神分裂症患者具有负面症状的社会功能障碍有关. 这些AMYG变化可能是改善社会运作的关键目标.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗成像医学成像
背景情况:
- 社会功能障碍是精神分裂症 (SCZ) 的主要特征,特别是在具有显著负面症状的个体中.
- 杏仁体 (AMYG) 对于情绪和社会处理至关重要,与SCZ相关的社会缺陷有关.
研究的目的:
- 调查桃体 (AMYG) 的结构和功能变化是否调解了精神分裂症 (SCZ) 中的负面症状和社会功能之间的关系.
主要方法:
- 在205名男性参与者中利用结构性和静止状态功能性MRI (53名SCZ赤字,76名非赤字SCZ,76名健康对照).
- 使用经过验证的尺度评估负面症状和社会功能.
- 分析了杏仁体 (AMYG) 容量,AMYG与其他大脑区域之间的功能连接 (FC),并对中介效应进行了路径分析.
主要成果:
- 与对照组相比,精神分裂症 (SCZ) 患者表现出双边杏仁体 (AMYG) 体积减少.
- 在SCZ组中,左桃体 (AMYG.L) 与非赤字SCZ (NDS) 相比,进一步减少了赤字SCZ (DS).
- 在DS患者中,左桃体 (AMYG.L) 和左上旋 (STG.L) 之间观察到功能连接 (FC) 的下降.
- 调解分析证实,左桃体 (AMYG.L) 体积及其与左上旋 (STG.L) 的FC部分调解了负面症状和社会功能受损之间的联系.
结论:
- 左桃体 (AMYG.L) 结构和功能的异常,特别是其与左上旋 (STG.L) 的连接性,在男性缺陷精神分裂症 (DS) 患者的社会功能障碍中起作用.
- 这些发现突出了左桃体 (AMYG.L) 作为旨在提高精神分裂症 (SCZ) 的社会结果的干预措施的潜在治疗目标.
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