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新辅助免疫治疗对头部和部状细胞癌患者听力的影响

Bryce Hambach^1,2, Anhelina Bilokon³, John Lee¹

¹Laboratory of Hearing Biology and Therapeutics, National Institute on Deafness and Other Communication Disorders (NIDCD), NIH, Bethesda, MD, USA.

Scientific reports

|July 29, 2025

概括

头癌的免疫检查点阻塞 (ICB) 治疗显示,立即听力损失的风险很低. 虽然大多数患者的听力稳定,但细微的耳变化表明长期监测很重要.

科学领域:

在瘤学瘤学.
耳鼻喉科耳鼻喉科耳鼻喉科
免疫学免疫学免疫学

背景情况:

免疫检查点封锁 (ICB) 是一种重要的癌症治疗方法.
耳毒性是ICB的潜在不良事件,但听力损失的风险尚不清楚.
接受ICB的头部和部状细胞癌 (HNSCC) 患者需要进行听力评估.

研究的目的:

评估ICB治疗患者的耳毒性和听力损失的风险.
为了确定ICB治疗后听力功能在临床上有意义的变化.

主要方法:

对接受新辅助ICB的HNSCC患者的回顾性图表审查.
听力测量数据 (纯音值值,DPOAEs,耳 tympanometry,词识别) 在治疗前后收集.
使用ASHA和CTCAEv5.0指南评估的耳毒性.

主要成果:

在12名患者中,只有1名符合听力值显著变化的标准.
没有观察到语音理解或中耳功能的显著差异.
扭曲产物耳声排放 (DPOAEs) 显示了变化,表明潜在的早期外部毛细胞损伤.

结论:

对晚期HNSCC的新辅助ICB似乎具有较低的急性耳毒性发病率.
微妙的耳变化需要长期监测听力,以发现潜在的延迟效应.
需要进一步的前性研究才能充分了解长期的耳毒性风险.

关键词:

头癌是头部和部的癌症.听力损失听力损失免疫检查点封锁 (ICB)长期监测长期监测长期监测新辅助疗法是一种新辅助疗法.耳部毒性耳部毒性

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