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Updated: Sep 13, 2025

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淋巴结衍生干状,但不是瘤组织的CD8+ T细胞燃料抗癌免疫力

Sharanya K M Wijesinghe1, Lisa Rausch1, Sarah S Gabriel1

  • 1Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Queensland, Australia.

Nature immunology
|July 29, 2025
PubMed
概括

淋巴结中的耗尽的T (TPEX) 细胞的前体,而不是瘤,驱动抗瘤免疫力和对免疫检查点阻塞 (ICB) 的反应. TGFβ限制了类似干细胞的TPEX细胞,阻碍了瘤控制.

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