肌瘤在发育和疾病中的疾病
Alexandria N Fusco1,2, Leif Oxburgh3, Thomas J Carroll4,5
1Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA.
Nature reviews. Nephrology
|July 29, 2025
概括
筋,管道之间的复杂细胞网络,对于器官的发育和功能至关重要. 需要进一步的研究才能充分理解这些神秘的树皮细胞及其在健康和疾病中的作用.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 发展生物学 发展生物学
- 细胞生物学 细胞生物学
背景情况:
- 脏包括复杂的上皮和内皮管,对于维持身体化学物质至关重要.
- 一个异质的细胞网络 - - 层体 (stroma) 位于这些管体之间,并越来越多地被认为具有支持作用.
- 流体细胞比其他细胞类型了解得更少,因此它们获得了脏的号"暗物质".
研究的目的:
- 为了审查肌瘤的发育起源.
- 描述当前关于细胞功能在脏发育和成人维护方面的知识.
- 确定关键未解答的问题和必要的资源,以推进脏 stromal 细胞的研究.
主要方法:
- 本综述综合了关于肌瘤的现有文献.
- 它整合了发育生物学,细胞生物学和病学研究的发现.
- 该综述侧重于树皮细胞的空间整合和通信作用.
主要成果:
- 流体细胞对于上皮质和内皮质的生长和模式至关重要.
- 它们在脏发育,维护和修复中起着重要作用.
- 有证据表明,树皮细胞介导了表皮和内皮组成部分之间的关键通信.
结论:
- 筋瘤对于的最佳功能,发育和修复至关重要.
- 更深入地了解树突细胞生物学对于解决脏疾病至关重要.
- 需要进一步的研究才能充分阐明这些复杂细胞的功能.
相关概念视频
Renal Corpuscle
3.3K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
3.3K
Nephrons
3.5K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.5K
Chronic Kidney Disease I: Introduction
73
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
73
Internal Anatomy of the Kidney
2.8K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
2.8K
Kidney Structure
70.5K
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
70.5K
External Anatomy of the Kidney
1.6K
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
1.6K


