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Updated: Sep 13, 2025

Methods to Increase the Sensitivity of High Resolution Melting Single Nucleotide Polymorphism Genotyping in Malaria
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测试负面设计与偏差校正的功率和样本大小考虑:关于世界上第一个疟疾疫苗的案例研究

Yura K Ko1,2, Tobias Alfvén3,4, Daisuke Yoneoka5

  • 1Department of Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, Stockholm, Sweden. yongra.ko@ki.se.

BMC medical research methodology
|July 29, 2025
PubMed
概括

测试负面设计 (TND) 评估疫苗有效性 (VE) 的研究可能会因不完善的诊断测试而产生偏见. 偏差校正提高了准确性,但需要更大的样本大小,特别是在低测试灵敏度的情况下.

关键词:
偏差纠正偏差的纠正疟疾:疟疾是一种疾病.样本的大小 样本大小统计能力 统计能力测试负面设计.疫苗的有效性 疫苗的有效性

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