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Updated: Sep 13, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
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药理性CLK抑制破坏SR蛋白功能和RNA剪接,阻断TNBC细胞生长和迁移

Nasi Liu1, Jurjun J S van der Velde1, Sherien Ramdjielal1

  • 1Division of Cell Systems and Drug Safety, Leiden Academic Centre for Drug Research, Leiden University, Einsteinweg 55, Leiden, 2333 CC, The Netherlands.

Breast cancer research : BCR
|July 29, 2025
PubMed
概括

使用T-025对Cdc2类激酶 (CLK) 的药理抑制会阻止三阴性乳腺癌 (TNBC) 细胞的增殖和迁移. T-025导致拼接因子的积累,重编程基因表达对TNBC进展至关重要.

关键词:
另一个替代拼接.类似于Cdc2的激酶.富含血清素/阿基宁的蛋白质.三阴性乳腺癌是三阴性乳腺癌.

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