一个基于RFH-NPT的诺姆图,用于预测肝硬化患者的长期存活率:一个多中心研究
Chengbin Zhu1,2,3,4, Yuchao Wu1,2,3,4,5, Fulian Zhao1,2,3,4
1Department of Infectious Diseases, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
European journal of clinical nutrition
|July 30, 2025
概括
营养不良显著影响肝硬化结局. 一个新的皇家免费医院营养优先级工具 (RFH-NPT) 模型准确地预测了患者的生存率,优于现有的方法.
科学领域:
- 肝病学和胃肠道学
- 临床预后 临床预后
- 营养科学 营养科学
背景情况:
- 肝硬化结果受到营养状况的显著影响.
- 现有的预后模型往往无法充分解决肝硬化患者的营养不良问题.
- 皇家免费医院营养优先级工具 (RFH-NPT) 旨在识别营养风险.
研究的目的:
- 开发和验证基于RFH-NPT的肝硬化患者的预后模型.
- 通过纳入营养风险评估来改善结果预测.
- 将新模型的性能与既有预测工具进行比较.
主要方法:
- 分析了152名肝硬化住院患者的培训队列.
- 使用了来自多个中心的320名肝硬化患者的验证队列.
- 使用考克斯建模,BSR和LASSO回归构建了一个名图,随访时间为5年.
- 绩效与儿童普格,MELD和MELD-Na分数进行了评估.
主要成果:
- 非幸存者 (81.1%) 的营养风险高于训练队列中幸存者 (46.5%) 的营养风险.
- 开发的诺米图表在预测1年,3年和5年的生存率方面表现出卓越的准确性.
- 诺莫图的预测性能在一个独立的队列中得到了验证.
结论:
- 营养不良在肝硬化预后中起着至关重要的作用.
- 已经建立了一个有效的基于RFH-NPT的模型,用于预测肝硬化患者的结果.
- 该工具通过整合营养评估,提供了更好的预后能力.
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