由小血管疾病引起的白质网络损伤以及对认知功能的影响
Natalie Busby1, Janina Wilmskoetter2, Roger Newman-Norlund3
1Department of Communication Sciences and Disorders, University of South Carolina, 915 Green Street, Columbia, SC, 29209, USA. hethern@mailbox.sc.edu.
Scientific reports
|July 30, 2025
概括
白质超强度 (WMHs) 影响特定的大脑通道,特别是在老年人中. 这些干扰与认知功能和记忆力下降有关.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 衰老研究研究 衰老研究
背景情况:
- 白质超强度 (WMHs) 在衰老中很常见,并与认知能力下降有关.
- 受到WMHs影响的精确白质道及其行为影响需要进一步调查.
- 了解特定于管道的WMH效应可以阐明认知障碍的机制.
研究的目的:
- 为了确定白质最受WMHs影响的区域.
- 确定在特定路径和认知表现中与WMH相关的断开之间的关联.
- 为了探索与年龄相关的白质管道完整性的变化.
主要方法:
- 参与者 (N=212,年龄20-80岁) 接受了认知评估 (MoCA).
- 白质超强度 (WMHs) 在FLAIRMRI扫描上手动划分.
- 使用DSIStudio和HCP 1065FIB模板量化了通道特定的WMH相关断开,然后与认知得分和年龄相关联.
主要成果:
- 年龄较大与多个通道的WMH相关断路增加相关,包括右弧形囊,极端囊,前部插入通道,双侧纵向囊和体.
- 右上纵向囊中与WMH相关的断裂与较低的整体MoCA得分有关.
- 右端囊,中间/上端纵向囊和双侧前端插入道的断开与较低的MoCA记忆指数得分相关.
结论:
- 白质超强度不成比例地影响特定的白质通道,特别是右半球的协会纤维,在老年人中患病率越来越高.
- 与通道特定的WMH相关的断开与全球认知功能和记忆性能有显著的关联.
- 与年龄相关的白质变性,特别是在特定区域,构成认知和记忆能力下降的风险.
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