巨细胞动脉炎的迹象和症状的词汇表
Medha L Soowamber1, Milena Bond2, Zahi Touma3
1Mount Sinai Hospital, Toronto, Ontario, Canada.
目的:
本研究旨在为医疗专业人员(主要在研究环境中)制定基于共识的巨细胞动脉炎(GCA)体征与症状的定义。
方法:
从先前在巨细胞动脉炎(GCA)应答标准制定过程中系统性文献综述所评估的11项随机对照试验中提取了GCA体征和症状的核心定义。该信息通过其他来源(如风湿病学教科书)的定义进行了补充。在一个国际工作组(来自11个国家的32名成员)中开展了两轮德尔菲法调查。第一轮旨在对定义每一项体征或症状的描述性术语达成共识,第二轮则对这些术语的重要性进行评分。基于德尔菲研究方法,制定了初步定义。通过4次在线会议,对德尔菲调查结果进行了审议,并就最终定义达成共识。
结果:
回顾了巨细胞动脉炎(GCA)的29种体征和症状。其中,已有6种GCA的体征或症状在既往文献中被明确定义。本研究对23种体征和症状的定义达成了高度共识,并确定以下12种为GCA的特征性表现:头痛、颞动脉异常、头皮压痛、头皮坏死、下颌跛行、舌跛行、舌坏死、一过性黑矇、永久性视力丧失、发热、肢体跛行及血压不对称。
结论:
通过国际专家的共识过程,制定了包含23种巨细胞动脉炎体征和症状定义的术语表。
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