检测结直肠癌的非侵入性呼吸检测:多中心,病例控制发展和验证研究 (COBRA2研究) 的协议
Michael G Fadel1, James Murray2, Georgia Woodfield1
1Department of Surgery and Cancer, Hammersmith Hospital Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
BMC cancer
|July 30, 2025
概括
一个新的呼吸测试显示了早期结肠直肠癌 (CRC) 检测的希望. 这种非侵入性方法可以通过及时诊断和治疗来改善患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 呼吸系统医学 呼吸系统医学
- 分析化学 分析化学
背景情况:
- 结肠直肠癌 (CRC) 是英国癌症死亡的主要原因,晚期诊断的生存率显著降低.
- 慢性肺癌的非特异性症状往往会延迟诊断,因此早期检测至关重要.
- 呼吸分析提供了一种潜在的非侵入性方法,用于检测CRC特有的挥发性有机化合物 (VOC).
研究的目的:
- 开发和验证使用呼吸测试检测结直肠癌的临床预测模型 (CPM).
- 探索将呼吸分析与便免疫化学测试 (FIT) 结合起来,以提高诊断准确性的潜力.
- 评估从CPM获得的患者分拣决策规则的临床实用性.
主要方法:
- 一项多中心病例控制研究 (COBRA2) 涉及720名参与者 (250名CRC,470名对照).
- 从接受结肠镜检查或确诊CRC的参与者收集的呼吸样本,通过气色谱-质谱分析.
- 用于开发CPM的统计和机器学习方法,在独立的队列中进行验证.
主要成果:
- 对VOC进行探索性分析,以确定CRC特定的标记物.
- 基于呼吸测试结果开发一个CPM.
- 评估是否结合FIT数据可以提高CPM的诊断性能.
结论:
- 非侵入性呼吸试验有可能更早,更准确地检测CRC.
- 这种方法可以提高患者的接受度,并促进及时的二级护理转诊.
- 成功验证可能会导致改善治疗治疗和CRC患者的存活率.
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