与表观遗传衰老减缓的营养关联:荷兰人口中的纯素饮食
Georges E Janssens1,2, Jenny van Dongen3, Lannie Ligthart3
1Laboratory Genetic Metabolic Diseases, Amsterdam UMC Location University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands.
Clinical epigenetics
|July 30, 2025
概括
素食饮食可能通过减少表观遗传年龄来减缓衰老过程. 这项研究发现,素食主义与表观遗传衰老得分较低有关,这表明基于植物的饮食可能会影响健康并降低医疗保健成本.
科学领域:
- 营养流行病学 营养流行病学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
背景情况:
- 由于人口老龄化,医疗保健成本不断上升,需要采取干预措施来延长健康寿命.
- 素食饮食显示出新出现的证据,证明它们有潜力减缓生物衰老过程.
研究的目的:
- 研究饮食习惯 (包括素食主义) 与表观遗传衰老之间的关联.
- 探索植物性饮食如何影响生物年龄标志物.
主要方法:
- 分析来自荷兰双胞胎登记 (n=22,124) 和表观遗传年龄的饮食数据,使用多个时钟 (Hannum,Horvath,PhenoAge,GrimAge,Dunedin Pace of Aging) 对DNA甲基化数据 (n=3049) 的分析.
- 统计调整包括年龄,性别,吸烟,教育,体力活动,BMI和小群体中酒精使用等混因素 (n=1198).
主要成果:
- 植物性饮食与改善的健康参数如BMI和胰岛素敏感性相关.
- 在调整了混因素后,素食主义与汉努姆和霍尔瓦斯时钟的表观遗传衰老得分较低有显著的关联.
- 禁食猪肉与较低的生物年龄有关,而禁食家禽与较高的生物年龄有关.
结论:
- 饮食选择,特别是素食主义,可能会影响表观遗传衰老,可能会降低生物年龄.
- 尽管样本大小和时间差距有限,但研究结果表明,植物性饮食可能是健康衰老的策略.
- 需要进一步的大规模队列研究和临床试验来证实这些关联.
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