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从BMI的动态变化角度来看:BMI轨迹与失糖症之间的关系,所有原因的死亡率
Buyu Guo1, Yichen Yang1, Na Wang1
1The First Clinical Medical College, Lanzhou University, Lanzhou, 730000, China.
Diabetology & metabolic syndrome
|July 30, 2025
概括
体重指数 (BMI) 轨迹显著影响2型糖尿病 (T2DM) 风险和死亡率. 体重变化,特别是早期的体重变化,是T2DM发展和进展的关键指标.
科学领域:
- 代谢健康 代谢健康
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 了解身体质量指数 (BMI) 轨迹对于代谢健康至关重要.
- 低血糖症,包括2型糖尿病 (T2DM) 和糖尿病前期,构成了全球重大健康挑战.
- 动态BMI变化与不良健康结果之间的关系需要进一步研究.
研究的目的:
- 为了探索BMI轨迹随时间的推移.
- 调查BMI轨迹与失糖症 (T2DM,糖尿病前期) 之间的关联.
- 检查BMI轨迹与全因死亡率和胰岛素耐药性之间的联系.
主要方法:
- 隐性类别轨迹模型 (LCTM) 用于识别不同的BMI轨迹.
- 后勤和考克斯回归分析评估了BMI轨迹/体重变化和T2DM/糖尿病前期之间的相关性.
- 线性回归评估了与胰岛素抵抗的关联,并探索了炎症的调解作用.
主要成果:
- 确定了四种BMI轨迹:稳定 (74.32%),轻度增加 (17.18%),快速增加 (2.82%) 和增加到减少 (5.67%).
- 与稳定相比,T2DM的更高风险与BMI轨迹略有增加或增加至减少有关.
- 轻微增加或快速增加的轨迹与更高的糖尿病前期概率相关;早期体重变化对T2DM风险产生了重大影响.
结论:
- 体重指数的轨迹和体重变化是T2DM风险和死亡率的关键决定因素.
- 特定的BMI变化模式,尤其是生命早期,与代谢失调有很强的联系.
- 这些发现强调了监测BMI动态对于预测和预防T2DM的重要性.
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