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相关概念视频

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview01:19

Inductively Coupled Plasma–Mass Spectrometry (ICP–MS): Overview

In inductively coupled plasma–mass spectrometry (ICP–MS), an inductively coupled plasma (ICP) torch is used as an atomizer and ionizer. Solid samples are dissolved and volatilized before being introduced into the high-temperature argon plasma, while solution samples are nebulized and passed through the high-temperature argon plasma. Plasma dissociates the analytes and ionizes their component atoms to form a mixture of positive ions and molecular species. The positive ions are then passed on to...

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基于参数规则的智能系统 (PRISM) 用于设计和分析高强度可分离的微针.

Sanghwi Ju1,2,3, Seung-Hyun Im3, Kyungsun Seo4

  • 1Graduate School of Data Science, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea.

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概括

一个名为PRISM的新系统设计了高强度可分离的微针,用于无痛的通过皮肤递送药物. 这种系统能够强大的穿透皮肤和可靠的脱落,优于传统的设计.

关键词:
药物输送是药物输送的过程.机械强度 机械强度 机械强度微型3D打印可以实现.参数设计是指参数设计.可以分离的微针.

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科学领域:

  • 生物材料科学 生物材料科学
  • 药物输送系统 药物输送系统
  • 生物医学工程 生物医学工程

背景情况:

  • 透皮微针系统提供最小侵入性的生物分子输送,减少疼痛.
  • 设计具有高强度的微针,以便轻松穿透皮肤和贴片脱落,仍然是一个挑战.

研究的目的:

  • 开发基于参数规则的智能系统 (PRISM) 用于设计和分析高强度可分离的微针.
  • 创建微针系统,实现强大的皮肤透和可靠的可分离输送.

主要方法:

  • 参数3D建模,基于几何的结构分析和微3D打印 (pμSL) 的整合.
  • 使用pμSL制造原型微针阵列.
  • 在模仿皮肤的幻影样本中进行机械测试和评估.

主要成果:

  • PRISM设计的微针显示出优越的机械性能:2.13 ± 0.51 N的轴阻和73.92 ± 34.77 mN的剪切断裂力.
  • 在模仿皮肤的幻影中成功分离了微针尖端.
  • PRISM设计实现了目标深度插入和分离,与传统设计不同,这些设计失败了.

结论:

  • PRISM平台可以创建高强度可分离的微针.
  • 这种方法为开发先进的透皮药物递送技术提供了一个有效的工具.
  • 开发的微针显示出改善治疗疗效和患者服从性的前景.