血清硬质素水平升高是患有高血压的患者周围动脉疾病的危险因素
Yahn-Bor Chern1, Po-Sheng Lee2, Ji-Hung Wang2,3,4
1Division of Nephrology, Department of Internal Medicine, Yuan's General Hospital, Kaohsiung 80249, Taiwan.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
升高的硬质素水平与高血压患者患外围动脉疾病 (PAD) 的风险更高有关. 斯克莱洛斯可以作为PAD早期检测和风险评估的生物标志物.
科学领域:
- 心血管医学 心血管医学
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- Wnt途径抑制剂,硬质素和dickkopf-1 (DKK1),都与血管化和动脉样硬化有关.
- 动脉样硬化外周动脉疾病 (PAD) 在高血压患者中很常见.
研究的目的:
- 研究血清Wnt通路抑制剂与高血压患者的PAD之间的关联.
- 为了评估这种人群中斯克莱洛斯和DKK1作为PAD的潜在生物标志物.
主要方法:
- 92名高血压患者的横截面研究.
- PAD的定义是脚-手臂指数<0.9.
- 测量了胆固醇,DKK1,C反应蛋白 (CRP) 和其他标记物的血清水平.
- 统计分析包括后勤回归和ROC曲线分析.
主要成果:
- 患有PAD的患者表现出显著更高的血清胆固醇和CRP水平.
- 斯克莱洛斯被确定为PAD的独立预测因子 (OR 1.054,p=0.002).
- 斯克莱洛斯对PAD (AUC 0.806,p<0.001) 的诊断能力很强,截止值为71.5 pmol/L.
结论:
- 血清硬质素水平独立地与高血压患者的PAD风险增加有关.
- 斯克莱罗斯显示出作为PAD风险分层和早期诊断的生物标志物的潜力.
- DKK1水平在各组之间没有显著差异,这表明硬质素的作用更为具体.
相关概念视频
Peripheral Artery Disease I: Introduction
33
Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
33
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation
35
Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
35
Coronary Artery Disease I: Introduction
58
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
58
Peripheral Artery Disease III: Interprofessional Care
29
Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
29
Atherosclerosis I: Introduction
87
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
87
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
40
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
40


