马林素1和CHI3L1水平表现出相反的趋势和与糖尿病病中功能障碍的相关性
Aykut Bulu1, Erhan Onalan2, Burkay Yakar3
1Department of Internal Medicine, Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
糖尿病脏病 (DN) 患者的马林素-1 (MaR1) 水平增加,与功能障碍标记物相关,表明MaR1是潜在的DN生物标记物. 基因酶-3样蛋白1 (CHI3L1) 水平下降,需要进一步调查.
科学领域:
- 内分泌学和新陈代谢学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 生物化学 生物化学
背景情况:
- 2型糖尿病 (T2DM) 和糖尿病病 (DN) 是全球主要的健康问题.
- 炎症和血液学标志物在T2DM和DN病变发生过程中发挥作用.
- 马雷辛-1 (MaR1) 和基因酶-3样蛋白1 (CHI3L1) 是新的生物标志物,在炎症和组织修复中具有潜在的作用.
研究的目的:
- 为了研究血清马雷辛-1 (MaR1) 和奇丁酶-3样蛋白1 (CHI3L1) 水平之间的关系.
- 评估MaR1和CHI3L1与T2DM和DN患者的炎症和血液学标志物的相关性.
- 探索MaR1和CHI3L1作为糖尿病病的生物标志物的潜力.
主要方法:
- 一项涉及90名参与者的横截面研究:30名健康对照,30名T2DM患者和30名DN患者.
- 血清中MaR1和CHI3L1水平使用酶相关免疫吸收试验 (ELISA) 进行测量.
- 评估生物化学和血液学参数;使用非参数测试和斯皮尔曼相关性进行统计分析.
主要成果:
- 与T2DM患者和对照患者相比,DN患者的血清MaR1水平显著更高 (p <0.01).
- 与对照组相比,DN患者的血清CHI3L1水平显著降低 (p = 0.007).
- 马R1与C反应蛋白 (CRP),血液尿素 (BUN) 和肌素正相关,与球过率 (GFR) 负相关. CHI3L1与GFR正相关,与BUN负相关.
结论:
- 与功能障碍标志物相关的DN患者的MaR1升高表明它有可能成为糖尿病病的预后生物标志物.
- 在DN中观察到的CHI3L1的减少需要进一步研究以阐明其作用.
- MaR1和CHI3L1需要进一步调查,因为它们是早期检测和监测糖尿病并发症的潜在指标.
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