在纤维肌痛中评估氧化应激:诊断实用性及其与临床和心理参数的关系
Emine Yıldırım Uslu1, Muhammed Fuad Uslu2, Sevler Yıldız3
1Department of Physical Medicine and Rehabilitation, Elazığ Fethi Sekin City Hospital, 23280 Elazig, Turkey.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
氧化应激标志物,如总氧化剂状态 (TOS),总抗氧化剂状态 (TAS) 和甲酸 (MDA) 在纤维肌痛综合征 (FMS) 中升高. 这些标记可能有助于诊断女性的FMS.
科学领域:
- 生物化学 生化学
- 临床医学 临床医学
- 病理生理学 病理生理学
背景情况:
- 纤维肌痛综合征 (FMS) 是一种复杂的慢性疼痛疾病.
- 人们越来越认识到氧化应激在FMS病变发生中的作用.
- 目前的FMS诊断方法可能是主观的,缺乏特定的生物标志物.
研究的目的:
- 评估纤维肌痛中氧化应激参数的诊断效用.
- 在FMS患者中探索氧化应激标志物与疾病严重程度,功能状态,焦虑和抑郁之间的相关性.
- 为了确定FMS诊断的潜在生化生物标志物.
主要方法:
- 测量了总抗氧化剂状态 (TAS),总氧化剂状态 (TOS) 和甲 (MDA) 的血清水平.
- 氧化应激指数 (OSI) 计算了42名FMS患者和42名健康对照.
- 纤维肌痛影响问卷 (FIQ),贝克抑郁症清单 (BDI) 和贝克焦虑清单 (BAI) 用于评估患者状态.
主要成果:
- 与对照组相比,在FMS组中观察到TOS,TAS,MDA和OSI的水平明显更高 (p < 0.001).
- 在FMS患者中,氧化应激标志物与心理或功能评分 (BDI,BAI,FIQ) 之间没有发现显著的关联.
- 当所有参与者一起分析时,发现了氧化应激标志物和其他生化参数 (CRP,AST,自由T4,HbA1c,费里丁,叶酸) 之间的相关性.
结论:
- 在患有纤维肌痛综合征的女性患者中,氧化压力的增加是明显的.
- TAS,TOS,MDA和OSI显示出作为FMS诊断生物标志物的潜力.
- 需要进一步的研究来阐明氧化应激和FMS病理生理学之间的复杂相互作用.
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