与免疫检查点抑制剂相关的肺毒性风险因素和生物标志物
Efraim Guzel1, Ismail Hanta1, Oya Baydar Toprak1
1Department of Chest Diseases, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
免疫检查点抑制剂 (ICI) 可以引起肺毒性. 这项研究确定了咳,COPD和低淋巴细胞/单细胞计数等危险因素,建议对ICI患者进行更密切的监测.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 免疫检查点抑制剂 (ICI) 是一种重要的癌症疗法.
- 与免疫相关的不良事件,特别是肺毒性,是显著的限制.
- 确定ICI诱导的肺毒性风险因素至关重要.
研究的目的:
- 为了确定ICI诱导的肺毒性发生率.
- 确定这种毒性的临床,实验室和放射性风险因素.
主要方法:
- 对126名接受ICI治疗的成年患者进行前性观察性研究.
- 两年后续,每六个月收集一次数据.
- 使用临床,实验室和放射学数据评估肺毒性.
主要成果:
- 与ICI相关的肺毒性发生在16.7%的患者中.
- 危险因素包括恶性瘤类型,肺癌,慢性肺炎,长期ICI使用,咳,呼吸不良,ICI前的肺结节和异常的单细胞水平.
- 回归分析显示,咳的风险增加 (7.70倍),COPD (4.57倍),淋巴细胞减少 (每单位0.998倍) 和单细胞减少 (≤130的11.75倍).
结论:
- 肺毒性是ICI治疗的一个重要问题.
- 患有已确定的风险因素的患者需要加强监测和早期评估.
- 积极管理可能会降低与ICI诱导的肺毒性相关的发病率和死亡率.
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