在妊娠期糖尿病中三季度特定的血清脂质概况:系统性审查,元分析和元回归
Milos Milincic1, Andja Cirkovic2, Katarina Ivanovic1
1Clinic for Gynecology and Obstetrics, University Clinical Centre of Serbia, 11000 Belgrade, Serbia.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
孕期糖尿病 (GDM) 显著改变孕妇的脂质特征,高甘油和改变胆固醇水平在怀孕早期最为突出. 早期发现和治疗GDM对于减轻这些不良的脂质变化至关重要.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
背景情况:
- 孕期糖尿病 (GDM) 是一个重要的公共卫生问题,与不利的孕产妇和新生儿结局有关.
- 怀孕自然会导致血清脂质谱的变化,在患有GDM的女性中,这种变化会加剧.
研究的目的:
- 综合评估和比较孕妇与没有GDM的脂质参数.
- 为了在不同季度中识别与GDM相关的特定脂质变化.
主要方法:
- 从PubMed,Web of Science和Scopus数据库中对研究进行系统审查和元分析.
- 包括研究测量甘油三 (TG),总胆固醇 (TC),LDL-C,HDL-C,VLDL-C和TG/HDL比率在怀孕妇女和没有GDM.
- 使用NOS和JADAD尺度进行质量评估,使用I2统计数据进行异质性评估,并通过漏斗图表进行出版偏差检查.
主要成果:
- 与对照人群相比,在GDM怀孕的三个季度都观察到高的TG和TG/HDL水平.
- 对于患有GDM的女性来说,在第一和第二季度观察到TC和LDL-C的显著增加.
- 脂质特征的变化在第一和第二个季度最明显.
结论:
- GDM与显著的脂质异常密切相关,包括TG升高和HDL-C降低.
- 这些脂质变化在怀孕早期表现出来,强调需要及时的GDM诊断和干预.
- 监测孕妇的脂质样本可以帮助在早期发现和管理GDM.
相关概念视频
01:22Diabetes Mellitus: Type 2 and Gestational
3.0K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
3.0K
01:20Pathophysiology of Diabetes
1.2K
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
1.2K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
295
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
295
01:27Glucose Transporters
24.1K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
24.1K
01:23Dipeptidyl Peptidase 4 Inhibitors
261
Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
261
01:22Diabetes Mellitus: Overview and Type I Subtype
3.3K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
3.3K