尿路膀癌中的肉症:叙述性综述
Constantin Radu Vrabie1,2, Andreea Ioana Parosanu1,3, Cornelia Nitipir1,4
1Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
麻症或肌肉损失在膀癌患者中很常见,并且会对预后和治疗结果产生负面影响. 需要进一步的研究来将肉类症纳入临床决策中,以便更好地评估患者的风险.
科学领域:
- 在瘤学瘤学.
- 老年病的医生 老年病的医生
- 身体组成分析 身体成分分析
背景情况:
- 泌尿器膀癌呈现出不同的分子和临床特征,进展风险可变.
- 标志着肌肉质量和功能丧失的萨科佩尼亚在所有膀癌阶段都非常普遍.
研究的目的:
- 审查和综合证据,关于在尿路膀癌中萨尔科佩尼亚的临床影响.
- 为了检查在整个膀癌疾病过程中,sarcopenia的动态变化.
主要方法:
- 使用PubMed,Scopus和Cochrane数据库进行了叙事文献审查.
- 搜索术语包括"膀癌"",肉类","身体组成"",NMIBC"和"MIBC".
- 案例报告和会议摘要被排除在外.
主要成果:
- 在非肌肉侵入性膀癌 (NMIBC) 中,肉可能具有负预测价值.
- 对于接受新辅助化疗 (NAC) 的肌肉侵入性膀癌 (MIBC),肉症与增加的毒性和治疗延迟有关.
- 肉症与更高的术后死亡率和激进手术后的并发症相关.
- 在转移性尿路细胞癌 (mUC) 中,较低的肌肉质量是负面的预后因素,并与化疗毒性相关,但不是irAEs.
结论:
- 麻症是膀癌患者中普遍存在且具有临床意义的表型,影响预后和治疗.
- 将肉症和身体组成分析整合到风险得分中可能会改善患者分层.
- 需要进行前性研究,以验证肉类的预后作用,并指导临床整合.
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