识别脆弱综合征生物标志物的挑战:系统性审查
Indira Omarova1, Ainur Yeshmanova1, Gulzhan Gabdulina1
1Department of General Medical Practice, Kazakh National Medical University Named After S.D. Asfendiyarov, 94 Tole bi, Almaty 050069, Kazakhstan.
Medicina (Kaunas, Lithuania)
|July 30, 2025
概括
本综述对脆弱综合征生物标志物进行了分类,包括血液,遗传,尿路和唾液类型. 关键的研究挑战涉及研究设计,不清楚的机制和测量变化.
科学领域:
- 老年学是指老年学的学科.
- 生物标志物研究 生物标志物研究
- 临床医学 临床医学
背景情况:
- 虚弱综合征显著影响老年人的健康和独立.
- 确定可靠的生物标志物对于早期检测和干预至关重要.
- 目前的文献介绍了一系列潜在的脆弱生物标志物.
研究的目的:
- 根据其生物材料来源对脆弱综合征生物标志物进行分类.
- 综合过去五年关于脆弱生物标志物的现有文献.
- 识别和分类脆弱生物标志物研究中的挑战.
主要方法:
- 在五个主要的电子数据库 (PubMed,Scopus,Web of Science,CINAHL,Cochrane Library) 进行系统的文献搜索.
- 包括2019年1月1日至2024年7月1日期间发表的研究.
- 定性数据综合和确定挑战的主题分类.
主要成果:
- 包括61项研究,包括56758名参与者和1479个独特的生物标志物.
- 生物标志物被分为血液,遗传,尿路和唾液类型.
- 发现的主要研究挑战包括研究设计的局限性,不清楚的病理生理机制和生物标志物特定问题.
结论:
- 对各种脆弱综合征生物标志物 (血液,遗传,尿路,唾液) 进行了广泛的研究.
- 显著的挑战阻碍了进步,包括方法上的不一致性和测量的变化.
- 更深入地了解潜在的病理生理机制对于推进脆弱生物标志物研究至关重要.
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