肠道微生物群和血代谢概况的疾病可能与淋巴结结核病结核病有关
Yun Long1,2, Jiamin Huang1, Shasha Zheng1
1Shenzhen Third People's Hospital, National Clinical Research Centre for Infectious Disease, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen 518112, China.
Microorganisms
|July 30, 2025
概括
肠道微生物群的改变与淋巴结结核病 (LNTB) 有关. 由于肠道失调而减少的短链脂肪酸 (SCFA) 可能为LNTB患者提供新的治疗途径.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 代谢学 代谢学 代谢学
背景情况:
- 淋巴结结核病 (LNTB) 与肠道微生物群的关联在很大程度上是未知的.
- 肠道微生物群在宿主健康和免疫力中起着至关重要的作用.
研究的目的:
- 研究肠道微生物群的作用及其对LNTB患者的代谢影响.
- 探索LNTB管理的潜在治疗目标.
主要方法:
- 肠道微生物群的元基因组测序.
- 血代谢学分析.
- 凯格路径分析和综合数据分析.
主要成果:
- 在LNTB患者中,肠道微生物多样性减少,特别是短链脂肪酸 (SCFA) 生产细菌.
- 肠道功能失调会对SCFA生物合成和新陈代谢产生负面影响.
- 在LNTB患者中观察到与SCFA合成和炎症相关的血代谢物的变化.
- 在特定的肠道细菌和血代谢产物之间发现了显著的相关性.
结论:
- 肠道微生物群失调和相关的代谢功能障碍降低了LNTB中的SCFA产量.
- 这些发现突出了LNTB管理的潜在新型治疗目标.
更多相关视频
13:50Sequencing of Bacterial Microflora in Peripheral Blood: our Experience with HIV-infected Patients
Published on: June 11, 2011
12.4K
10:04Analysis of 18FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates
Published on: September 5, 2017
18.9K
相关概念视频
Pulmonary Tuberculosis III
446
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
446
Pulmonary Tuberculosis IV
206
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
206
Pulmonary Tuberculosis I
326
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
326
Pulmonary Tuberculosis II
362
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
362
Pulmonary Tuberculosis V
239
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
239
