在与功能性便秘作斗争的儿童中的微生物群-救援调节器
Nicoleta Ana Tomșa1, Lorena Elena Meliț2, Teodora Popescu1
1Doctoral School of Medicine and Pharmacy, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu Street, No. 38, 540136 Targu Mures, Romania.
Microorganisms
|July 30, 2025
概括
儿童的功能性便秘与肠道微生物群的变化有关. 益生菌有望通过恢复有益细菌和减少炎症来改善症状,尽管需要更多的研究来标准化使用.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 功能性便秘 (FC) 影响30%的儿童,95%的病例是功能性便秘.
- FC涉及肠周平静的变化,受免疫系统,神经系统,胆酸代谢和肠道微生物群的影响.
研究的目的:
- 审查肠道微生物群在儿科便秘中的作用.
- 评估益生菌在治疗儿童便秘方面的有效性.
主要方法:
- 对小儿功能性便秘中的肠道微生物群和益生菌研究的文献综述.
- 分析慢性FC中的微生物群组成变化.
- 评估益生菌的作用机制.
主要成果:
- 慢性FC中肠道微生物群的变化显示了Bacteroidetes,Enterobacteriaceae和Firmicutes的增加,而Prevotella,Bifidobacteria,Faecalibacterium prausnitzii和Clostridium leptum的减少.
- 益生菌包括Bifidobacterium breve,Bifidobacterium longum和Bifidobacterium animalis亚种等,它们可以帮助我们改善健康. 乳糖XLTG11可能会增加排便频率,减少便失禁和腹部疼痛.
- 乳酸菌通过有机酸的生产来增强肠道的运动性和便的湿度.
结论:
- 肠道微生物群的改变在儿科功能性便秘中很明显.
- 特定的益生菌菌株表明对便秘症状有潜在的益处.
- 目前,研究异质性限制了儿童便秘管理中的益生菌标准化.
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