在Cyberlindnera jadinii中使用短链脂肪酸用于单细胞蛋白和奇数链脂肪酸生产
Christian Hermansen1, Rowanne Siao1, Gi Gi Chua1
1Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology, and Research (A*STAR), 31 Biopolis Way, Nanos, Singapore 138669, Singapore.
Microorganisms
|July 30, 2025
概括
这项研究表明,酵母Cyberlindnera jadinii可以将短链脂肪酸转化为有价值的单细胞蛋白和脂质. 酸产生了最高的蛋白质产量,证明了循环经济的可持续生物工艺.
科学领域:
- 生物技术是生物技术.
- 微生物发酵 微生物发酵
- 可持续的蛋白质生产可持续的蛋白质生产
背景情况:
- 全球对可持续蛋白质来源的需求不断增长.
- 短链脂肪酸 (SCFA) 是丰富的,适合生物处理的废物衍生化合物.
- 非传统酵母Cyberlindnera jadinii作为SCP生产的潜在平台.
研究的目的:
- 调查SCFA (乙酸盐,酸盐,丁酸盐) 作为基质用于Cyberlindnera jadinii.的单细胞蛋白 (SCP) 生产.
- 为了优化生物工艺,提高SCP和脂肪酸生产.
- 为了评估产生的生物质的组成.
主要方法:
- 在混合生物反应器中培养Cyberlindnera jadinii,使用SCFA作为碳和能源.
- 开发一种养批量pH-stat生物工艺,以减轻基质抑制.
- 对生物质组成的分析,包括原蛋白,原脂和脂肪酸概况.
主要成果:
- 网络lindnera jadinii有效地利用了酸盐,酸盐和丁酸盐,没有显著的抑制.
- 用合剂生物处理实现了最高标位为31.3g/L,速率为0.67g/L/h,使用酸盐的产量为0.36g/g.
- 由此产生的生物质含有41.3%的原始蛋白质和17.3%的原始脂质 (81%不和),使用propionate时含有37%的奇数链脂肪酸.
结论:
- 使用Cyberlindnera jadinii,SCFA是生产单细胞蛋白和有价值的脂肪酸的可行的基质.
- 开发的生物工艺在循环生物经济中为资源利用提供了一个可持续的途径.
- 赛博林德纳·贾迪尼 (Cyberlindnera jadinii) 显示出不仅可以生产蛋白质,还可以生产特定的脂肪酸,包括奇数链脂肪酸.
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