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在哺乳羊中,饮食蛋白质诱导的古代组成动力学,甲生路径和抗菌素耐药性概况的变化
Maida Mushtaq1,2, Xiaojun Ni1,2,3,4, Muhammad Khan1,2
1Yunnan Animal Science and Veterinary Institute, Jindian, Panlong District, Kunming 650000, China.
Microorganisms
|July 30, 2025
概括
饮食中的蛋白质对绵羊肠道的古老菌有重大影响,影响其多样性和甲产量. 高蛋白质增加了抗性基因,而中等蛋白质促进了古生物的多样性,这表明优化的饮食可以改善肠道健康并减少对环境的影响.
科学领域:
- 流体微生物学 流体微生物学
- 动物营养动物营养
- 环境科学环境科学
背景情况:
- 肠道古生物在反动物的消化和温室气体的产生中起着至关重要的作用.
- 饮食中的蛋白质是影响肠道微生物群的关键因素,但其对绵羊中古生物的具体影响尚未完全理解.
研究的目的:
- 调查不同饮食蛋白质水平对肠道古老社区组成,功能能力和相关抗菌素耐药性 (AMR) 基因对绵羊的影响.
- 确定不同蛋白质摄入量如何影响甲产量和潜在的健康风险.
主要方法:
- 绵羊被养低,中,或高原蛋白饮食大约202天.
- 用16S rRNA和元基因组学测序分析了便样本.
- 考古物种的多样性,组成,功能途径,AMR基因和毒性因子被评估.
主要成果:
- 与低蛋白相比,在中等和高蛋白饮食中观察到更高的考古物种多样性和丰富性.
- 甲原生属如 *Methanobrevibacter * 繁多,并受到蛋白质摄入的影响.
- 高蛋白饮食显著丰富了抗微生物耐药性基因和毒性因子,并增强了甲原性活性.
结论:
- 饮食中的蛋白质水平显著塑造了羊的肠道古老生态系统,影响了多样性,基因含量和功能.
- 中等蛋白质饮食促进了古生物的多样性,而高蛋白质饮食增加了AMR基因的流行率和甲的产生.
- 优化食蛋白质可以改善肠道健康,减轻抗抗药性风险,并减少甲排放,以实现可持续的畜牧业生产.
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