健康的衰老和肠道微生物群:关于成人长寿的研究
Lihua Deng1, Jun Xu2,3, Qian Xue1
1Department of Geriatrics, Peking University People's Hospital, Beijing 100044, China.
Microorganisms
|July 30, 2025
概括
长寿成人的肠道微生物群显示出更高水平的有益细菌,如Akkermansia和Bifidobacterium,这些细菌与更好的身体功能和健康的衰老有关. 这些微生物变化可能标志着衰老过程,并作为长寿的生物标志物.
科学领域:
- 老年学是一门学科.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道微生物群与衰老中的身体功能之间的关系,特别是在百岁以上的人中,尚不清楚.
- 对长寿个体的肠道微生物群的研究可以提供对健康衰老机制的见解.
研究的目的:
- 探索长寿的成年人肠道微生物群组成和功能的变化.
- 调查肠道微生物群与这个队列中的身体功能之间的关联.
主要方法:
- 一项前性观察性研究,涉及51名老年人 (≥60岁,包括27名≥90岁的人).
- 评估临床数据,身体功能 (老年人综合护理 - ICOPE工具,通过短物理性能电池 (SPPB) 掌握力) 和饮食习惯.
- 肠道微生物群结构和功能通路的元基因组学分析.
主要成果:
- 长寿成年人 (长寿组,90-98岁) 的内在能力 (ICOPE分数) 比对照组 (60-89岁) 低.
- 长期组的肠道微生物群富含阿克尔曼西亚和Bifidobacterium.
- 肠道微生物群与牛奶消费,焦虑和身体功能 (握力) 相关联. 特定细菌 (Bacteroides plebeius,Bacteroides eggerthii) 在具有更好的身体功能的长寿成年人中增加.
- 氨基酸合成途径 (L-异氨酸,L-氨酸,L-氨酸) 在具有更好的身体功能的长寿成年人中过度表现.
结论:
- 长寿的成年人表现出明显的肠道微生物群形状,与身体功能相关的有益细菌的丰富性更高.
- 肠道微生物群的变化可能会先于临床衰老指标,并可以作为长寿和健康衰老的潜在生物标志物.
- 营养和情绪状态被确定为对肠道微生物群和衰老结果的重要影响因素.
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